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Aluminum can be present in our bodies through several routes. For instance, it can be stored in muscles, bones, and liver. It can also be absorbed through the skin and lungs.
Aluminum has been associated with neurodegenerative diseases. These include Alzheimer's disease. The high-level concentrations of aluminium in the CNS may lead to the formation of neurofilibary tangles. In addition, aluminum promotes the aggregation of B amyloid peptide in mice. This process is believed to occur because of the conversion of membrane proteins.
Many studies have examined the effect of aluminium on the brain and the nervous system. However, there is no direct evidence of adverse health effects in animals. Nevertheless, the accumulating pathological amyloid deposits in the brain of Alzheimer's patients have been linked to aluminium exposure.
Aluminium is currently regulated in food and water. It is also present in the environment. Some unprocessed foods contain aluminum naturally.
The DOSE/dictionary of substances and their effects is published by the Royal Society of Chemistry. This dictionary provides an overview of the various substances that can be found in the human body.
Studies have shown that aluminum oxide can cause irritation to the eyes and respiratory tract. This can be caused by mechanical eye irritation or by irritation due to a chemical reaction with the cornea.
Another study investigated how skin telangiectases of aluminum workers react to the metal. A rare isotope 26Al was applied to the armpit of two subjects for 53 days. They then excreted the 26Al in their urine.