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Aluminium oxide nanoparticles are used in a variety of applications including new construction composites, cement, industrial and environmental catalysts, electronics and optical devices. They are also being manipulated for drug delivery, tumor-specific hyperthermia therapy, analytical assays, contrast agents and real-time sensing.
Synthesis of aluminium oxide nanoparticles
Several techniques are available for synthesising Aluminium oxide nanoparticles that include pyrolysis, sputtering, sol gel and the most common method which is laser ablation which can be done in the liquid, gas or vacuum environment. This technique is more convenient as it can be done at low temperatures and with minimal purity requirements.
AlOxNPs are a very interesting class of nanoparticles for many reasons as they have a range of desirable properties from a chemical standpoint to a structural perspective. These NPs possess high surface area, high mechanical strength and excellent chemical stability towards harsh environments such as abrasion and high temperatures.
Antifungal application of Aluminum Oxide Nanoparticles
The antifungal property of these nanoparticles has been shown to be very effective against a wide variety of bacteria, yeast and molds. This is due to the fact that these particles not only adhere to the surface but they penetrate inside the cell and inhibit its physiological activity as well as causing morphological changes in the fungus.
Cytotoxicity of Aluminum Oxide Nanoparticles
Cytotoxicity of these nanoparticles has been shown in some studies to be low, with no effects on eukaryotic cells. This is in contrast to many other NPs that show potential for being toxic to a variety of biological entities, some of which have been linked to cancer.